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1lq), mice got new bedding and 16 h of food deprivation (ZT10ZT2) followed by an injection of drug or vehicle injection at ZT2 and refeeding with SD (30 min after injection for danuglipron and liraglutide

Lower estrogen levels reduce leptin sensitivity, meaning the satiety hormone becomes less effective at signaling fullness

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Rodent studies have shown that brain-derived GLP-1 is primarily produced by neurons in the lower brainstem that express preproglucagon (PPG), with a particular enrichment in the nucleus of the solitary tract (NTS) and adjacent medullary regions

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